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Application Note - Immobilized pepsin digestion of Cytochrome-C

ProDx columns

Download: Application Note - Immobilized pepsin digestion of Cytochrome-C [PDF]

Components
  1. Equine Cytochrome-C
View full product details
 

Brochure - Automated Hydrogen-Deuterium Exchange

Download: Brochure - Automated Hydrogen-Deuterium Exchange [PDF] View full product details
 

Brochure - Automated Hydrogen-Deuterium Exchange (Japanese)

水素重水素置換反応装置
フレキシブルな機能

Download: Brochure - Automated Hydrogen-Deuterium Exchange (Japanese) [PDF] View full product details
 

LEAP HDX automation

Contact a workflow specialist for your specific needs

Flexibility by design

Since 2002 Trajan has been automating HDX, providing continuous enhancements for rugged HDX sample control and scheduling.

Trajan’s LEAP HDX system is the recognized leader, preferred around the globe by scientists requiring confidence in reproducible results.

Features and benefits

Automated HDX provides structural confidence in native states
HDX, especially automated HDX, has uses in development, manufacturing and post-production, providing insight into your protein’s tertiary structure, in its native state(s).

Successful HDX experiments are all about control
With robotic precision, Trajan’s HDX platform exerts exacting control of all key factors:

  • Reproducible accuracy in timing of liquid transfers – overlapped to ensure efficiency.
  • Maintained pH control – optimizes quench conditions for maximum sequence coverage.
  • Sustained 0°C environment – precision at temperatures from 0°C to biological conditions.
  • In-line digestion – fully leverages and identifies ideal digestion conditions.

Recommended applications

HDX is a well-established analytical technique for protein-ligand, protein-protein, protein-conjugate interactions and protein stability studies.

HDX uses variations in deuterium exchange rates between more and less accessible/structured regions throughout a protein.

In addition to being faster than other protein techniques like x-ray crystallography and NMR, HDX data can be obtained from samples that are challenging to crystalize and from samples in short supply. It can be used to replicate critical native state conditions, for the most useful results. HDX is an indispensable complementary tool for protein biophysics.

Trajan’s HDX system is compatible with bottom-up, top- and middle-down protein analysis studies.

More

  • The total HDX platform
    Our total HDX platform covers the complete process: sample input >> the many meticulous steps of preparation >> optimizing mass spec utilization >> clear answers with minimal manual data curation.

    Faster answers
    Powerful information on protein structure in days – not weeks. Move more quickly, make better decisions.

    With HDExaminer, swiftly and easily analyze data from any MS instrument to get a complete picture of the overall deuteration behavior of your protein.

  • Automation at its finest
    The most efficient system control, with unique temperature set points at all stages of the experiment to ensure reliable data. Sustained 0°C environment reduces back exchange, improves sample stability and overall reproducibility.

    Our Chronos for HDX software offers a streamlined interface for HDX users and automatically overlaps time points for maximum MS efficiency.

    Combines ease of use with advanced options, allowing promotion of user-defined parameters to the sample list, giving the operator control over all aspects of the method without complication.

    ChronosHDX screenshot

    HDExaminer: a complete analytical tool for HDX experiments

    The Trajan LEAP HDX platform works natively with HDExaminer from Sierra Analytics, a complete software solution for HDX analysis, independent of MS data type.

    HDExaminer is designed with ease of use in mind, offering numerous ways to visualize your data. These include:

    • Deuteration level residue maps give you quick insight into the most important areas for study.
    • Protein state comparisons help you to spot differences in ligand-bound vs. unbound, mutant vs. wild type, modified vs. unmodified etc.
    • Zoom in on all individual residue results with isotope clusters, extracted ion chromatograms and color-coded confidence levels (vs. theoretical data).

    Unique fluidics automation for the best performance
    Trajan’s LEAP HDX platform incorporates an advanced cooling chamber for the trapping and chromatography phases which includes an enclosed valve and column chiller as well as solvent pre-conditioning.

    Digestion temperature is controlled independently with the protease column chamber, to allow improved digestion efficiency.

    A special 3 valve configuration enables zero-downtime backflushing for retention time stability, extended column life and superior carryover protection.

    Optimized fittings and precut tubing ensure maximum reliability and instrument up-time.

  • Specifications

    Compact

    Base

    Parallel (standard)

    Parallel (extended)

    Automatic syringe selection for extended dynamic range

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    ✔

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    Chilled syringe for quench/injection

    ✔

    ✔

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    Vial capacity for 100 time point experiments

    ✔

    ✔

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    Optimized valve fluidics for inline digestion and automatic backflushing

    ✔

    ✔

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    Exchange time points down to 30 seconds

    ✔

    ✔

    ✔

    ✔

    Independent protease column temperature control

    ✔

    ✔

    ✔

    ✔

    Trajan HDX syringes

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    Trajan ProDx protease columns optimized for low temperature

    ✔

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    Trajan ProDx trap columns optimized for low temperature

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    Dual head for simultaneous operations

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    -

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    Exchange time points down to 15 seconds

    -

    -

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    Forward compatible capacity for future models

    -

    -

    Optional

    ✔

    Secondary chilled syringe for protein handling

    -

    -

    Optional

    Optional

    Membrane protein filtration

    -

    Optional

    Optional

    Optional

    96 or 384 well microtiter plate capacity

    Optional

     

    Optional

    Optional

    Optional

  • Expert training
    Trajan Scientific and Medical is the global expert in HDX automation. Our in-house specialists and experienced partners offer the best training and consulting available to achieve your HDX goals.

    Supporting more operation modes in more places than ever
    With 40 years combined experience in HDX and coupled to our unparalleled relationships with the global leaders in the technique worldwide, our HDX automation continues to offer application support for an ever-expanding portfolio of options.

    New features and integrations now offer you better access to membrane proteins, proteins at biologically relevant temperatures, and even more flexible protein regions than ever before.

    The Trajan LEAP HDX platform is supported directly by Trajan in Europe, Australia, Japan and the USA, and through partners in the Middle East, India and beyond.

    Service you can trust
    Our CTC manufacturer-certified service team is available to assist you in person, by phone and remote session.

    Now offering local time zone support in US, EU, ANZ and Asiatic time zones.

    Available extended support contracts, training and preventative maintenance schedules.

  • Consumables designed for HDX
    Columns and fluidics specifically designed to optimize all aspects of the HDX user experience. From ease of use to reliability and sample stability, your success is our number one goal.

    ProDx Protease columns are designed to perform with lower carryover, lower backpressure, and better digestion characteristics at 0°C for longer lifetimes.

    ProDx Trap columns are uniquely engineered to operate under HDX experimental conditions.

    View the range of ProDx columns

View full product details

 

Part Number List - ProDx columns

Download: Part Number List - ProDx columns [PDF]

Also see: Product Data Sheet - ProDx Protease columns
Also see: Product Data Sheet - ProDx trap columns

Find in table:

Part number Part description and detail
Protease
PDX.PP01-F32 30 mm x 2.1 mm ID ProDx Protease (Pepsin) bio-inert stainless steel glass lined column
Trap
PDX.T8H02-32 20 mm x 530 µm ID ProDx C8 Analog* trap column PK3 (with 1/16" to 10-32 UNF thread PEEKLok™ UHPLC fittings (6 x adaptor ferrules, 2 x hex head fittings))

*This product contains POROS® material used under license for Sample Prep purposes from Life Technologies Corporation, a subsidiary of Thermo Fisher Scientific, Inc. The POROS® Trademark is owned by Thermo Fisher Scientific, Inc.

View full product details
 

Part Number List - Replacement needles for CTC PAL autosampler syringes

Download: Part Number List - Replacement needles for CTC PAL autosampler syringes [PDF]

Find in table:

Part number
(*needle and
plunger kit)		 Part description and detail Needle gauge Needle OD (mm) Needle length (mm) Needle tip Pack size For use with syringe(s)
For LC
031590 5.7 cm 1.07 mm OD 0.65 mm ID LC tipped needle for 5-10 mL CTC RTC and Thermo RSH syringes PK2 19 1.07 57 LC 2 008951
037880 5.7 cm 0.72 mm OD LC tipped needle for 10 µL CTC RTC and Thermo RSH syringes PK2 22 0.72 57 LC 2 002880
038250 5.1 cm 0.72 mm OD LC tipped needle for 25-500 µL syringes PK5 22 0.72 51 LC 5 005330, 006330
039280 5.7 cm 0.72 mm OD LC tipped needle for 1-2.5 mL CTC RTC and Thermo RSH syringes PK2 22 0.72 57 LC 2 008151
For GC
033780* 5.7 cm 0.63 mm OD cone tipped needle for 0.5 µL NanoVolume CTC RTC and Thermo RSH syringes PK1 23 0.63 57 Cone 1 000480
034780* 5.7 cm 0.63 mm OD cone tipped needle for 1.0 µL NanoVolume CTC RTC and Thermo RSH syringes PK1 23 0.63 57 Cone 1 000680
036011 5 cm 0.63 mm OD cone tipped needle for 5 µL syringes PK2 23 0.63 50 Cone 2 001984
036871 5.7 cm 0.63 mm OD cone tipped needle for 5 µL CTC RTC and Thermo RSH syringes PK2 23 0.63 57 Cone 2 001871
036873 8.5 cm 0.47 mm OD cone tipped needle for 5 µL CTC RTC and Thermo RSH syringes PK2 23 0.63 85 Cone 2 001873
037787 5 cm 0.63 mm OD cone tipped needle for 10 µL CTC/Thermo syringes PK2 23 0.63 50 Cone 2 002984, 0029841
037871 5.7 cm 0.63 mm OD cone tipped needle for 10 µL CTC RTC and Thermo RSH syringes PK2 23 0.63 57 Cone 2 002871, 002872
037873 8.5 cm 0.63 mm OD cone tipped needle for 10 µL CTC RTC and Thermo RSH syringes PK2 23 0.63 85 Cone 2 002873, 002874
033772* 5 cm 0.63 mm OD cone tipped needle for 0.5 µL NanoVolume CTC/Thermo syringes 23 0.63 50 Cone 1 000492
031535 8 cm 0.47 mm OD cone tipped needle for 10 µL CTC/Thermo syringes PK3 26 0.47 80 Cone 3 0029931
036875 5.7 cm 0.47 mm OD cone tipped needle for 5 µL CTC RTC and Thermo RSH syringes PK2 26 0.47 57 Cone 2 001875
036877 8.5 cm 0.47 mm OD cone tipped needle for 5 µL CTC RTC and Thermo RSH syringes PK2 26 0.47 85 Cone 2 001877, 002877, 002878
037010 5 cm 0.47 mm OD cone tipped needle for 10 µL syringes PK2 26 0.47 50 Cone 1 002982, 002985
037875 5.7 cm 0.47 mm OD cone tipped needle for 10 µL CTC RTC and Thermo RSH syringes PK2 26 0.47 57 Cone 2 002875, 002876
038732 5 cm 0.47 mm OD cone tipped needle for 25-500 µL CTC/Thermo syringes PK2 26 0.47 50 Cone 2 005333
038749 5 cm 0.47 mm OD side-hole dome tipped needle for 25-500 µL syringes PK2 26 0.47 50 Side-hole 2 003988
033770* 5 cm 0.47 mm OD cone tipped needle for 0.5 µL NanoVolume CTC/Thermo syringes PK1 26 0.47 50 Cone 1 000490
034905* 5 cm 0.63 mm OD cone tipped needle for 2.0 µL NanoVolume CTC/Thermo syringes PK1 23 0.63 50 Cone 1 000790
View full product details
 

Part Number List - Syringes and needles for LEAP autosamplers

Part Number List - Syringes and needles for LEAP autosamplers [PDF]

Find in table:

Part number Part description and detail Needle gauge Needle OD (mm) Needle length (mm) Needle tip Barrel OD (mm) PTFE plunger tip Replacement needle
(*needle and
plunger kit)		 Replacement plunger
GC applications
CombiPAL, Combi-xt and GC PAL syringes
Fixed needle
001700 5 µL fixed needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for CTC autosampler, TriPlus 26 0.47 50 Cone 6.5   - -
001981 5 µL fixed needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for CTC autosampler, TriPlus 23 0.63 50 Cone 6.5   - -
002977 10 µL gas tight, fixed needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for CTC autosampler 26 0.47 50 Cone 6.5 P - 031803
002976 10 µL fixed needle CTC/Thermo syringe with gas tight plunger and 5 cm 0.47 mm OD (26 gauge), cone tipped needle PK6  26 0.47 50 Cone 6.5 P - 031803
002700 10 µL fixed needle, 50 mm needle length, 0.47 mm needle OD (26 gauge), cone tipped, for CTC autosampler 26 0.47 50 Cone 6.5   - -
002981 10 µL fixed needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for CTC autosampler, Thermo, TriPlus, AS3000, AS2000, AS200, AS800, Varian 8400, 8410, CP-9010, CP-9050 23 0.63 50 Cone 6.5   - -
002971 10 µL fixed needle, for CTC Thermo autosampler, TriPlus, AS3000, AS2000, AS200, AS800, 5 cm 0.63 mm OD (23 gauge), cone tipped needle, PK6  23 0.63 50 Cone 6.5   - -
002987 10 µL gas tight, PTFE tipped plunger, fixed needle, 50 mm needle length, 0.63 mm needle OD (23 gauge), cone tipped, for CTC autosampler, Thermo, TriPlus, AS2000 23 0.63 50 Cone 6.5 P - 031803
002972 10 µL fixed needle, for CTC Thermo autosampler, TriPlus, AS2000, gas tight, PTFE tipped plunger, 5 cm 0.63 mm OD (23 gauge), cone tipped needle PK6  23 0.63 50 Cone 6.5 P - 031803
002983 10 µL gas tight, PTFE tipped plunger, fixed needle, 50 mm needle length, 0.72 mm needle OD (22 gauge), side-hole dome tip, for CTC autosampler 22 0.72 50 Side-hole 6.5 P - 031803
003987 25 µL fixed needle, for CTC/Thermo autosampler, PTFE tipped plunger, gas tight, 5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 50 Cone 6.5 P - 031817
003700 25 µL fixed needle, for CTC autosampler, PTFE tipped plunger, gas tight, 5 cm 0.47 mm OD (26 gauge) cone tipped needle 26 0.47 50 Cone 6.5 P - -
005700 100 µL fixed needle, for CTC autosampler, PTFE tipped plunger, gas tight, 5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 50 Cone 6.5 P - 0318261
005335 100 µL fixed needle, for CTC/Thermo autosampler, PTFE tipped plunger, gas tight, 5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 50 Cone 6.5 P - 0318261
006700 250 µL fixed needle, for CTC autosampler, PTFE tipped plunger, gas tight, 5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 50 Cone 8 P - 0318926
007700 500 µL fixed needle, for CTC autosampler, PTFE tipped plunger, gas tight, 5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 50 Cone 8 P - 0318928
Removable needle
000490 0.5 µL plunger-in-needle (6.5mm OD barrel), removable needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, for CTC autosampler, Thermo, TriPlus, AS3000 26 0.47 50 Cone 6.5   033770* 033770*-
000492 0.5 µL plunger-in-needle (6.5mm OD barrel), removable needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, for CTC autosampler, Thermo, TriPlus, AS3000 23 0.63 50 Cone 6.5   033772* 033772*
000790 2µL plunger-in-needle (8 mm OD barrel), removable needle,50 mm needle length, 0.63 mm needle OD (23 gauge), for CTC autosampler, Thermo TriPlus, AS3000 23 0.63 50 Cone 0.47   034905* 034905*
001984 5 µL removable needle, 50 mm needle length, 0.63 mm needle OD (23 gauge), cone tipped, for CTC autosampler 23 0.63 50 Cone 6.5   036011 -
002982 10 µL removable needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for CTC autosampler, Thermo, TriPlus, AS3000, AS2000, Varian 8400, 8410, CP-9010, CP-9050 26 0.47 50 Cone 6.5   037010 -
002985 10 µL gas tight, PTFE tipped plunger, removable needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for CTC autosampler 26 0.47 50 Cone 6.5 P 037010 0318121
002984 10 µL removable needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for CTC autosampler, Thermo, triplus, AS3000, AS2000, AS200, AS800 23 0.63 50 Cone 6.5   037787 -
003988 25 µL removable needle, for CTC/Thermo autosampler, PTFE tipped plunger, gas tight, 5 cm 0.47 mm OD (26 gauge), side-hole needle 26 0.47 50 Side-hole 6.5 P 038749 031816
005333 100 µL removable needle, for CTC/Thermo autosampler, PTFE tipped plunger, gas tight, 5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 50 Cone 6.5 P 038732 031826
PAL3, RTC, RSI, LSI syringes
Removable needle
000480 0.5 µL NanoVolume CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.63 mm OD (23 gauge) cone tipped needle 23 0.63 57 Cone     033780 033780
000680 1.0 µL NanoVolume CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.63 mm OD (23 gauge) cone tipped needle 23 0.63 57 Cone     034780 034780
001871 5 µL removable needle CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 23 0.63 57 Cone     036871 -
001873 5 µL removable needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone     036873 -
001875 5 µL removable needle CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone     036875 -
001877 5 µL removable needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone     036877 -
002871 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone     037871 -
002872 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone   P 037871 032810
002873 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone     037873 -
002874 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone   P 037873 032810
002875 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone     037875 -
002876 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone   P 037875 032810
002877 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone     037877 -
002878 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone   P 037877 032810
PAL3, RTC, RSI, LSI syringes
Fixed needle
001861 5 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone     - -
001863 5 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone     - -
001865 5 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone     - -
001867 5 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone     - -
002861 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone     - -
002862 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone   P - 032810
002863 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone     - -
002864 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone   P - 032810
002865 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone     - -
002866 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone   P - 032810
002867 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone     - -
002868 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone   P - 032810
002869 10 µL fixed needle CTC RTC and Thermo RSH autosampler syringe with 8.5 cm 0.47 mm OD (26 gauge), Bevel tippedNeedle 26 0.47 85 Bevel     - -
003862 25 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone   P - 032815
003864 25 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone   P - 032815
003866 25 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone   P - 032815
003868 25 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone   P - 032815
004862 50 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone   P - 032821
004864 50 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone   P - 032821
004866 50 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone   P - 032821
004868 50 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone   P - 032821
005862 100 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone   P - 032825
005864 100 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone   P - 032825
005866 100 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone   P - 032825
005868 100 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone   P - 032825
005890 100 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 57 Side-hole   P - 032825
005891 100 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 85 Side-hole   P - 032825
006862 250 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone   P - 032831
006864 250 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone   P - 032831
006866 250 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone   P - 032831
006868 250 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone   P - 032831
006890 250 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 57 Side-hole   P - 032831
006891 250 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 85 Side-hole   P - 032831
007862 500 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 57 Cone   P - 032835
007864 500 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), cone tipped needle 23 0.63 85 Cone   P - 032835
007866 500 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 57 Cone   P - 032835
007868 500 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.47 mm OD (26 gauge), cone tipped needle 26 0.47 85 Cone   P - 032835
007890 500 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 57 Side-hole   P - 032835
007891 500 µL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 8.5 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 85 Side-hole   P - 032835
Antek syringes
Fixed needle
0039871 25 µL fixed needle syringe with gas tight plunger and 5 cm 0.63 mm OD (23 gauge) cone tipped needle, old style plunger for certain Antek instruments 23 0.63 50 Cone   P - -
Thermo TriPlus syringes 
Fixed needle
001981 5 µL fixed needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for CTC autosampler, TriPlus 23 0.63 50 Cone     - -
001982 5 µL fixed needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for CTC autosampler, Thermo TriPlus 26 0.47 50 Cone     - -
002967 10 µL fixed needle, for CTC Thermo autosampler, TriPlus, AS3000, AS2000, AS200, AS800, 5 cm 0.50 mm OD (25 gauge), cone tipped needle 25 0.50 50 Cone     - -
002971 10 µL fixed needle, for CTC Thermo autosampler, TriPlus, AS3000, AS2000, AS200, AS800, 5 cm 0.63 mm OD (23 gauge), cone tipped needle, PK6  23 0.63 50 Cone     - -
002972 10 µL fixed needle, for CTC Thermo autosampler, TriPlus, AS2000, gas tight, PTFE tipped plunger, 5 cm 0.63 mm OD (23 gauge), cone tipped needle PK6  23 0.63 50 Cone   P - 031803
002980 10 µL fixed needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for CTC autosampler, Thermo, TriPlus, AS3000, AS2000, AS200, AS800 26 0.47 50 Cone     - -
002981 10 µL fixed needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for CTC autosampler, Thermo, TriPlus, AS3000, AS2000, AS200, AS800, Varian 8400, 8410, CP-9010, CP-9050 23 0.63 50 Cone     - -
002986 10 µL fixed needle, 50 mm needle length, 0.47 mm needle OD (26 gauge), cone tipped, 6 pack, for CTC autosampler, Thermo, TriPlus 26 0.47 50 Cone     - -
002987 10 µL gas tight, PTFE tipped plunger, fixed needle, 50 mm needle length, 0.63 mm needle OD (23 gauge), cone tipped, for CTC autosampler, Thermo, TriPlus, AS2000 23 0.63 50 Cone   P - 031803
002992 10 µL fixed needle, 0.47 mm needle OD (26 gauge), 80 mm needle length, cone tipped, for CTC autosampler, Thermo TriPlus 26 0.47 80 Cone     - -
Removable needle
000490 0.5 µL plunger-in-needle (6.5mm OD barrel), removable needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, for CTC autosampler, Thermo, TriPlus, AS3000 26 0.47 50 Cone     - 033770
000492 0.5 µL plunger-in-needle (6.5mm OD barrel), removable needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, for CTC autosampler, Thermo, TriPlus, AS3000 23 0.63 50 Cone     - 033772
000790 2µL plunger-in-needle (8 mm OD barrel), removable needle,50 mm needle length, 0.63 mm needle OD (23 gauge), for CTC autosampler, Thermo TriPlus, AS3000 23 0.63 50 Cone     034905* 034905*
002982 10 µL removable needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for CTC autosampler, Thermo, TriPlus, AS3000, AS2000, Varian 8400, 8410, CP-9010, CP-9050 26 0.47 50 Cone     037010  -
002984 10 µL removable needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for CTC autosampler, Thermo, triplus, AS3000, AS2000, AS200, AS800 23 0.63 50 Cone     037787  -
002993 10 µL removable needle, 0.47 mm needle OD (26 gauge), 80 mm needle length, cone tipped, for CTC autosampler, Thermo, TriPlus 26 0.47 80 Cone     031535  - 
Thermo AS3000 syringes
Fixed needle
0019811 5 µL plunger-in-needle (8 mm OD barrel), 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, sheathed, Thermo AS3000, AS2000 23 0.63 50 Cone     - -
0019821 5 µL plunger-in-needle (8 mm OD barrel), 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, sheathed, Thermo AS3000, AS2000 26 0.47 50 Cone     - -
0029671 10 µL fixed needle syringe with 5 cm 0.50 mm OD (25 gauge), cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200 25 0.50 50 Cone     - -
0029761 10 µL fixed needle syringe with gas tight plunger and 5 cm, 0.47 mm OD (26 gauge) cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200, PK6  26 0.47 50 Cone   P - 03181201
0029771 10 µL gas tight, fixed needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for Thermo AS3000, AS2000, AS200/800 26 0.47 50 Cone   P - 03181201
0029801 10 µL fixed needle, plunger-in-needle (8 mm barrel OD), 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for Thermo AS3000, AS2000, AS200/800 26 0.47 50 Cone     - -
0029861 10 µL fixed needle syringe with 5 cm, 0.47 mm OD (26 gauge) cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200, PK6  26 0.47 50 Cone     - -
Removable needle
000490 0.5 µL plunger-in-needle (6.5mm OD barrel), removable needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, for CTC autosampler, Thermo, TriPlus, AS3000 26 0.47 50 Cone     - 033770
000492 0.5 µL plunger-in-needle (6.5mm OD barrel), removable needle, 0.63 mm needle OD (23 gauge), 50 mm needle length, for CTC autosampler, Thermo, TriPlus, AS3000 23 0.63 50 Cone     - 033772
000790 2µL plunger-in-needle (8 mm OD barrel), removable needle,50 mm needle length, 0.63 mm needle OD (23 gauge), for CTC autosampler, Thermo TriPlus, AS3000 23 0.63 50 Cone     034905* 034905*
0029841 10 µL removable needle, plunger-in-needle (8 mm barrel OD), 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for Thermo AS3000, AS2000, AS200/800 23 0.63 50 Cone     037787 -
Thermo AS2000 syringes
Fixed needle
0019811 5 µL plunger-in-needle (8 mm OD barrel), 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, sheathed, Thermo AS3000, AS2000 23 0.63 50 Cone     - -
0019821 5 µL plunger-in-needle (8 mm OD barrel), 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, sheathed, Thermo AS3000, AS2000 26 0.47 50 Cone     - -
0029671 10 µL fixed needle syringe with 5 cm 0.50 mm OD (25 gauge), cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200 25 0.50 50 Cone     - -
0029741 10 µL fixed needle syringe with 8cm, 0.72 mm OD (22 gauge) cone tipped needle, for Thermo autosampler AS2000 22 0.72 80 Cone     - -
0029761 10 µL fixed needle syringe with gas tight plunger and 5 cm, 0.47 mm OD (26 gauge) cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200, PK6  26 0.47 50 Cone   P - 03181201
0029771 10 µL gas tight, fixed needle, 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for Thermo AS3000, AS2000, AS200/800 26 0.47 50 Cone   P - 03181201
0029781 10 µL fixed needle, plunger-in-needle (8 mm barrel OD), 0.47 mm needle OD (26 gauge), 70 mm needle length, cone tipped, for Thermo AS2000 26 0.47 70 Cone     - -
0029801 10 µL fixed needle, plunger-in-needle (8 mm barrel OD), 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for Thermo AS3000, AS2000, AS200/800 26 0.47 50 Cone     - -
0029861 10 µL fixed needle syringe with 5 cm, 0.47 mm OD (26 gauge) cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200, PK6  26 0.47 50 Cone     - -
0029871 10 µL gas tight, fixed needle, plunger-in-needle (8 mm barrel OD), 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for Thermo AS2000 23 0.63 50 Cone   P - 03181201
0029891 10 µL gas tight, fixed needle, plunger-in-needle (8 mm barrel OD), 0.63 mm needle OD (23 gauge), 80 mm needle length, cone tipped, for Thermo AS2000 23 0.63 80 Cone     - -
0029921 10 µL fixed needle, 80 mm needle length, 0.47 mm needle OD (26 gauge), cone tipped, for Thermo AS2000 26 0.47 80 Cone     - -
Removable needle
0029841 10 µL removable needle, plunger-in-needle (8 mm barrel OD), 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for Thermo AS3000, AS2000, AS200/800 23 0.63 50 Cone     037787 -
0029931 10 µL removable needle, 80 mm needle length, 0.47 mm needle OD (26 gauge), cone tipped, for Thermo AS2000 26 0.47 80 Cone     031535 -
Thermo AS200/800 syringes
Fixed needle
0029671 10 µL fixed needle syringe with 5 cm 0.50 mm OD (25 gauge), cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200 25 0.50 50 Cone     - -
0029761 10 µL fixed needle syringe with gas tight plunger and 5 cm, 0.47 mm OD (26 gauge) cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200, PK6  26 0.47 50 Cone   P - 03181201
0029801 10 µL fixed needle, plunger-in-needle (8 mm barrel OD), 0.47 mm needle OD (26 gauge), 50 mm needle length, cone tipped, for Thermo AS3000, AS2000, AS200/800 26 0.47 50 Cone     - -
0029861 10 µL fixed needle syringe with 5 cm, 0.47 mm OD (26 gauge) cone tipped needle, for Thermo autosamplers AS3000, AS2000, AS800/200, PK6  26 0.47 50 Cone     - -
Removable needle
0029841 10 µL removable needle, plunger-in-needle (8 mm barrel OD), 0.63 mm needle OD (23 gauge), 50 mm needle length, cone tipped, for Thermo AS3000, AS2000, AS200/800 23 0.63 50 Cone     037787 -
GC headspace applications
CombiPAL, Combi-xt headspace syringes 
Fixed needle
008131 1.0 mL fixed needle CTC headspace syringe with energized gas tight plunger and 5.6cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 56 Side-hole 7.6 P   031841
008136 1.0 mL fixed needle CTC headspace syringe with energized gas tight plunger and 5.6cm 0.47 mm OD (26 gauge), side-hole needle 26 0.47 56 Side-hole 7.6 P   031841
008631 2.5mL fixed needle CTC headspace syringe with energized gas tight plunger and 5.6cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 56 Side-hole 9.7 P - 031851
008636 2.5mL fixed needle CTC headspace syringe with energized gas tight plunger and 5.6cm 0.47 mm OD (26 gauge), side-hole needle 26 0.47 56 Side-hole 9.7 P - 031851
008831 5mL fixed needle CTC headspace syringe with energized gas tight plunger and 5.6cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 56 Side-hole 14 P - -
PAL3, RTC, RSI headspace syringes
Fixed needle
008155 1.0 mL fixed needle CTC RTC autosampler and Thermo RSH headspace syringe with energized gas tight plunger and 6.5 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 65 Side-hole   P - 032841
008655 2.5mL fixed needle CTC RTC autosampler and Thermo RSH headspace syringe with energized gas tight plunger and 6.5 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 65 Side-hole   P - 032846
008855 5mL fixed needle CTC RTC autosampler and Thermo RSH headspace syringe with energized gas tight plunger and 6.5 cm 0.63 mm OD (23 gauge), side-hole needle 23 0.63 65 Side-hole   P - -
LC applications
HTS, HTC, LC PAL, HTS-xt, HTC-xt syringes
Fixed needle
002710 10 µL fixed needle, 51 mm needle length, 0.72 mm needle OD (22 gauge), LC tip, for CTC autosampler 22 0.72 51 LC 6.5   - -
002715 10 µL fixed needle, 51 mm needle length, gas tight, PTFE plunger tip, 0.72 mm needle OD (22 gauge), LC tip, for CTC autosampler 22 0.72 51 LC 6.5 P - 031803
003715 25 µL fixed needle, CTC autosampler, PTFE tipped plunger, gas tight, 5.1cm 0.72 mm OD (22 gauge), LC needle, 8 mm OD barrel 22 0.72 51 LC 7.6 P - 0318922
004810 50 µL fixed needle, CTC autosampler, PTFE tipped plunger, gas tight, 5.1cm 0.72 mm OD (22 gauge), LC needle 22 0.72 51 LC 6.5 P - 031821
005715 100 µL fixed needle, CTC autosampler, PTFE tipped plunger, gas tight, 5.1cm 0.72 mm OD (22 gauge), LC needle 22 0.72 51 LC 6.5 P - 0318261
005720 100 µL fixed needle, CTC autosampler, PTFE tipped plunger, gas tight, 5.1cm 0.72 mm OD (22 gauge), 0.4 mm ID LC needle 22 0.72 51 LC 6.5 P - 0318924
005331 100 µL fixed needle CTC/Thermo syringe with gas tight plunger and 5.1cm 0.72 mm OD (22 gauge), LC needle 22 0.72 51 LC 6.5 P   0318261
006720 250 µL fixed needle, CTC autosampler, PTFE tipped plunger, gas tight, 5.1cm 0.72 mm OD (22 gauge), LC needle 22 0.72 51 LC 8 P - 0318926
007720 500 µL fixed needle, CTC autosampler, PTFE tipped plunger, gas tight, 5.1cm 0.72 mm OD (22 gauge), 0.4 mm ID LC needle 22 0.72 51 LC 8 P - 0318928
Removable needle
005330 100 µL removable needle, CTC Thermo autosampler, PTFE tipped plunger, gas tight, 5.1cm 0.72 mm OD (22 gauge), LC needle 22 0.72 51 LC 6.5 P 038250 0318261
006330 250 µL removable needle, CTC autosampler, PTFE tipped plunger, gas tight, 5.1cm 0.72 mm OD (22 gauge), 0.4 mm ID LC needle 22 0.72 51 LC 6.5 P 038250 031831
008120 1 mL removable needle, CTC autosampler, PTFE plunger tip, gas tight, 51 mm needle, 22 g, with LC tip, 7.6 mm barrel OD 22 0.72 51 LC 7.6 P 039180 0318444
008820 5mL removable needle, CTC autosampler, PTFE plunger tip, gas tight, 51 mm needle, 22 g, with LC tip, 14 mm barrel OD 22 0.72 51 LC 14 P 031535 0318564
PAL3, RTC, RSI, LSI syringes
Removable needle
002880 10 µL removable needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 5.7 cm 0.72 mm OD (22 gauge), LC needle 22 0.72 57 LC   P 037880 032810
008151 1.0 mL removable needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.72 mm OD (22 gauge), LC tipped needle 22 0.72 57 LC   P 039280 032842
008951 10 mL removable needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 5.7 cm 1.07 mm OD (19 gauge) ID LC tipped needle 19 1.07 57 LC   P 031590 032855
PAL3, RTC, RSI, LSI syringes
Fixed needle
008150 1.0 mL fixed needle CTC RTC autosampler and Thermo RSH syringe with gas tight plunger and 5.7 cm 0.72 mm OD (22 gauge), LC tipped needle 22 0.72 57 LC   P - 032842
008950 10 mL fixed needle CTC RTC and Thermo RSH autosampler syringe with gas tight plunger and 5.7 cm 1.07 mm OD (19 gauge) LC tipped needle 19 1.07 57 LC   P - 032855
MS applications
MS removable needle syringes. needle available separately
CTC PALs syringes (no needle included)
002770 10 µL gas tight, removable needle, Diamond version, for CTC autosamplers, syringe body and plunger only, needle available separately           P - 0355170
003770 25 µL removable needle CTC MS syringe with gas tight plunger, syringe body and plunger only, needle available separately           P - 0355171
004770 50 µL removable needle CTC MS syringe with gas tight plunger, syringe body and plunger only, needle available separately           P - 0355172
005770 100 µL removable needle CTC MS syringe with gas tight plunger, syringe body and plunger only, needle available separately           P - 0355173
CTC RTC, RSI, LSI PALs syringes (no needle included)
002790 10 µL gas tight, removable needle, Diamond version, for Thermo RSH and CTC RTC autosamplers, syringe body and plunger only, needle available separately           P - 0355190
003790 25 µL removable needle CTC RTC and Thermo RSH autosampler MS syringe with gas tight plunger, syringe body and plunger only, needle available separately           P - 0355191
004790 50 µL removable needle CTC RTC and Thermo RSH autosampler MS syringe with gas tight plunger, syringe body and plunger only, needle available separately           P - 0355192
005790 100 µL removable needle CTC RTC and Thermo RSH autosampler MS syringe with gas tight plunger, syringe body and plunger only, needle available separately           P - 0355193
MS treated needles
To be used with MS syringe sizes 10 µL - 50 µL for LC CTC PALs (CTC RTC, RSI, LSI choose 57 mm)
0355210 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth hydrophilic treatment, for 10-50 µL PK1 22 0.72 51 LC     - -
0355215 Needle, MS, 57 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth hydrophilic treatment, for 10-50 µL PK1 22 0.72 57 LC     - -
0355220 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth hydrophobic treatment, for 10-50 µL PK1 22 0.72 51 LC     - -
0355225 Needle, MS, 57 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth hydrophobic treatment, for 10-50 µL PK1 22 0.72 57 LC     - -
0355230 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth, for 10-50 µL PK1 22 0.72 51 LC     - -
0355235 Needle, MS, 57 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth, for 10-50 µL PK1 22 0.72 57 LC     - -
To be used with MS syringe sizes 10 µL - 50 µL for GC CTC PALs
0355510 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth hydrophilic treatment, for 10-50 µL PK1 23 0.63 50 Cone     - -
0355512 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.11 mm ID, cone tipped, ultra smooth hydrophilic treatment, for 10-50 µL PK1 23 0.63 50 Cone     - -
0355520 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth hydrophobic treatment, for 10-50 µL PK1 23 0.63 50 Cone     - -
0355522 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.11 mm ID, cone tipped, ultra smooth hydrophobic treatment, for 10-50 µL PK1 23 0.63 50 Cone     - -
0355530 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth, for 10-50 µL PK1 23 0.63 50 Cone     - -
0355532 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.11 mm ID, cone tipped, ultra smooth, for 10-50 µL PK1 23 0.63 50 Cone     - -
To be used with MS syringe sizes 10 µL - 50 µL for GC CTC RTC, RSI, LSI PALs
0355610 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth hydrophilic treatment, for 10-50 µL PK1 23 0.63 57 Cone     - -
0355612 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.11 mm ID, cone tipped, ultra smooth hydrophilic treatment, for 10-50 µL PK1 23 0.63 57 Cone     - -
0355620 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth hydrophobic treatment, for 10-50 µL PK1 23 0.63 57 Cone     - -
0355622 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.11 mm ID, cone tipped, ultra smooth hydrophobic treatment, for 10-50 µL PK1 23 0.63 57 Cone     - -
0355630 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth, for 10-50 µL PK1 23 0.63 57 Cone     - -
0355632 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.11 mm ID, cone tipped, ultra smooth, for 10-50 µL PK1 23 0.63 57 Cone     - -
To be used with MS 100 µL syringe for GC CTC PALs
0355511 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth hydrophilic treatment, for 100-500 µL PK1 23 0.63 50 Cone     - -
0355521 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth hydrophobic treatment, for 100-500 µL PK1 23 0.63 50 Cone     - -
0355531 Needle, MS, 50 mm long, for CTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth, for 100-500 µL PK1 23 0.63 50 Cone     - -
To be used with MS 100 µL syringe for GC CTC RTC, RSI, LSI PALs
0355611 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth hydrophilic treatment, for 100-500 µL PK1 23 0.63 57 Cone     - -
0355621 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth hydrophobic treatment, for 100-500 µL PK1 23 0.63 57 Cone     - -
0355631 Needle, MS, 57 mm long, for Thermo RSH/CTC RTC autosamplers, 0.63 mm OD (23 gauge)/0.24 mm ID, cone tipped, ultra smooth, for 100-500 µL PK1 23 0.63 57 Cone     - -
To be used with MS syringe sizes 100 µL - 500 µL for LC CTC PALs (CTC RTC, RSI, LSI choose 57 mm)
0355211 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth hydrophilic treatment, for 100-500 µL PK1 22 0.72 51 LC     - -
0355213 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.37 mm ID, LC tip, ultra smooth hydrophilic treatment, for 100-500 µL PK1 22 0.72 51 LC     - -
0355216 Needle, MS, 57 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth hydrophilic treatment, for 100-500 µL PK1 22 0.72 57 LC     - -
0355221 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth hydrophobic treatment, for 100-500 µL PK1 22 0.72 51 LC     - -
0355223 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.37 mm ID, LC tip, ultra smooth hydrophobic treatment, for 100-500 µL PK1 22 0.72 51 LC     - -
0355226 Needle, MS, 57 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth hydrophobic treatment, for 100-500 µL PK1 22 0.72 57 LC     - -
0355231 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth, for 100-500 µL PK1 22 0.72 51 LC     - -
0355233 Needle, MS, 51 mm long, 0.72 mm OD (22 gauge)/0.37 mm ID, LC tip, ultra smooth, for 100-500 µL PK1 22 0.72 51 LC     - -
0355236 Needle, MS, 57 mm long, 0.72 mm OD (22 gauge)/0.17 mm ID, LC tip, ultra smooth, for 100-500 µL PK1 22 0.72 57 LC     - -

Every effort has been made to ensure the items suggested here are suitable, however the appropriateness for individual applications must remain the responsibility of the user.

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Performance Report - ProDx Protease column

Download: Performance Report - ProDx Protease column [PDF]

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Product Data Sheet - ProDx Protease columns

Download: Product Data Sheet - ProDx Protease columns [PDF]

Also see: Part Number List - ProDx columns

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Product Data Sheet - ProDx trap columns

Download: Product Data Sheet - ProDx trap columns [PDF]

Also see: Part Number List- ProDx columns

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ProDx Protease columns

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ProDx consumables are specifically designed and developed for use with the LEAP HDX platform.

The ProDx Protease column is optimized to perform at 0°C, the ideal temperature for performing HDX reactions.

Improved protease coupling reduces carryover from non-specific binding, while lower backpressures minimize the potential for contamination and overpressure leakage.

When used in combination with the new LEAP HDX valve system, it can be backflushed automatically to remove frit-loaded or undigested intact material. Clean columns give consistent retention times, overcoming traditional issues with non-selective binding and poor reproducibility.

To ensure confidence in your data, combine the ProDx Protease and trap columns for your HDX work

Features and benefits

  • Improve workflow efficiencies and reduce instrument downtime
  • Low temperature operation optimized at 0°C
  • Lower carryover and increased desalting efficiency
  • High pressure hardware designed for continuous use at 20,000 psi (1,379 bar)
  • More overlapping fragments for high confidence data
  • Automated backflushing when used with the LEAP HDX system

Recommended applications

Automated Hydrogen-Deuterium Exchange (HDX) experiments using the LEAP HDX platform.

Product specifications

ProDx columns were developed specifically for use with the LEAP HDX system. Packed in bio-inert stainless steel glass lined columns to withstand high pressure digestion practices, making it compatible with other systems.

  • ID configuration: 2.1 mm
  • Length configuration: 30 mm

The ProDx Protease (Pepsin) column is the first in a range of immobilized Protease columns available from Trajan. The initial intended use is with the LEAP HDX workflow, where these columns are used in-line for protein-protein and protein-ligand studies. The columns can be deployed outside of the HDX workflow as appropriate, possible alternate configurations might include general proteomics workflows, protein purification studies and QC applications. Column chemistry is such that limited exposure to common denaturing reagents and quenching salts (such as 6.4M Guanidine Hydrochloride, 8M Urea and 4M TCEP) do not adversely impact proteolytic performance.

ProDx Protease (Pepsin) columns are delivered chilled for optimal performance. Columns need to be maintained between 2-8°C. Column performance can be reduced if the column is maintained and operated above 15°C for extended periods of time, or if exposed to non-acidified aqueous reagents or organic reagents.

Phase Pore size (Å) Particle size (µm)
Protease (Pepsin)* 500-10,000 Å 20 μm

More

Please refer to the part number list for more items.

*This product contains POROS® material used under license for Sample Prep purposes from Life Technologies Corporation, a subsidiary of Thermo Fisher Scientific, Inc. The POROS® Trademark is owned by Thermo Fisher Scientific, Inc.

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ProDx trap columns

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ProDx consumables are specifically designed and developed for use with the LEAP HDX platform.

ProDx trap columns are optimized for maximum recovery of peptide fragments, efficient desalting and low backpressures during the digestion and elution processes of HDX runs.

While many columns used for HDX trapping are not designed for use with low temperature HDX systems, ProDx trap columns are designed to operate down to 0°C, with consistent recovery, and demonstrate reduced backpressure at standard conditions of 200 μL/min, 100% Aqueous and 0°C, lowering instances of leakage and need for troubleshooting.

ProDx trap columns are pre-configured with PEEKsil® lines for ease of use, reducing the number of fittings needed in the system, preventing issues that commonly occur when relying on other columns with multiple connections.

To ensure confidence in your data, combine the ProDx Protease and trap columns for your HDX work

Features and benefits

  • High recovery of peptide fragments generated by inline digestion.
  • Does not interfere with analytical separation.
  • Low temperature operation optimized at 0°C.
  • Lower carryover and increased desalting efficiency.
  • PEEKsil lines for reduced backpressure and leakage.
  • End frits designed to prevent rapid blocking by intact proteins and aggregates.
  • Phase and pore size to suit your analysis.

Recommended applications

Automated Hydrogen-Deuterium Exchange (HDX) experiments using the LEAP HDX platform.

Product specifications

ProDx columns were developed specifically for use with the LEAP HDX system. ProDx trap columns are designed to protect the ProDx analytical column.

  • ID configuration: 0.5 mm
  • Length configuration: 20 mm

Currently available in C8 Analog*, with performance similar to C18 materials, suitable for reversed-phase separation of biomolecules such as proteins and peptides.

Fittings for ProDx trap columns

PEEKLok™ UHPLC fittings are designed specifically for PEEKsil tubing: reliable, affordable, and easy to use, holding up to 22,000 psi; or up to 15,000 psi when used with ProDx trap columns.

PEEKLok UHPLC fittings Pressure rating Maximum operating pressure rating when used with ProDx trap columns
1/16" to 10-32 UNF 22,000 psi (>1,500 bar) 15,000 psi (1,000 bar)

More

Please refer to the part number list for more items.

*This product contains POROS® material used under license for Sample Prep purposes from Life Technologies Corporation, a subsidiary of Thermo Fisher Scientific, Inc. The POROS® Trademark is owned by Thermo Fisher Scientific, Inc.

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Technical Poster - Automated Hydrogen-Deuterium Exchange with optimized consumables

HDX

Download: Technical Poster - Automated Hydrogen-Deuterium Exchange with optimized consumables [PDF]

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